Abstract
Monocyte chemoattractant protein 1 (MCP-1) is the ligand for CCR2, a minor co-receptor of HIV-1. In 1059 HIV-1-infected children in the United States the MCP-1-2518-G allele was marginally associated with central nervous system (CNS) impairment at study entry. Alone or in combination with CCR2-64I, the MCP-1-2518-G allele did not alter disease progression or subsequent CNS impairment. These findings differ from studies in adults and suggest that MCP-1-CCR2 interactions may play a different role in HIV-1 immunopathogenesis of children.
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