Impact of matrix metalloproteinase-1 gene variations on risk of acute coronary syndrome

Abstract

This case-control study was conducted to investigate whether genetic variations in the matrix metalloproteinase-1 gene promoter were related to risk of acute coronary syndrome (ACS). 222 patients with ACS and 191 normal controls were examined by means of polymerase chain reaction (PCR) and restriction fragment length polymorphism. A significantly higher frequency of AA genotype of -519A/G polymorphism was observed in ACS patients than in the controls (P<0.001). The relative risk of ACS in patients carrying A allele of -519A/G polymorphism was 1.33 [P<0.001, 95% confidence interval (CI)=1.12-1.57]. Linkage disequilibrium test and haplotype analysis indicated that the AT haplotype significantly increased the risk of ACS (P=0.004, 95% CI=1.14-2.04, odds ratio=1.53). Compared with the AT haplotype, the GT haplotype was associated with a reduced occurrence of ACS (P<0.001, 95% CI=0.36-0.70, odds ratio=0.51). Our findings suggested that genetic variations in the matrix metalloproteinase-1 gene promoter may contribute to interindividual variability in risk of ACS, and help predict susceptible individuals.