Impact of maternal obesity on body weight regulation and sleep time in offspring

Abstract

Mississippi Center for Obesity Research, University of Mississippi Medical Center – Jackson, MS. There is limited understanding of the mechanisms that link parental obesity to adverse metabolic outcomes in their offspring. In this study we examined factors that influence body weight regulation and sleep time in mice fed a high fat diet after weaning (HFD, n=5) that were offspring of dams also fed a HFD (45% fat) and compared them to HFD fed mice (n=5) from dams on a control diet. Food intake was measured daily and body weight and body composition (EchoMRI) were measured weekly. Energy expenditure (EE), oxygen consumption (VO2), motor activity (MA) and sleep time (Sable System 40 sec criterion) were monitored for 5 consecutive days at 22 weeks of age. There were no significant differences in calorie intake (17.3±0.7 vs. 16.2±0.8 kcal/day), fasting blood glucose (170±13 vs. 187±16 mg/dL), total EE (5.7±0.6 vs. 5.7±0.2 kcal/hr), VO2 (1.5±0.1 vs. 1.7±0.1 ml/min) or MA (57±6 vs. 65±5 m/day) in offspring from dams fed a HFD compared to offspring from dams fed a control diet. However, there were significant increases in body weight (47.3±1.5 vs. 42.4±1.1 g) and fat mass (19.8±0.6 vs. 15.7±1.6 g), and decreased sleep time (8.6±0.2 vs. 9.7±0.2 hr/day, p=0.005) in offspring of dams fed a HFD. These results suggest that maternal obesity increases body weight and fat mass in offspring fed a HFD, and reduces sleep time without altering food intake, VO2, EE, MA, or fasting glucose levels in adult mice (NHLBI PO1HL51971, NIGMS P20GM104357 and NIGMS U54GM115428)Support or Funding InformationNHLBI PO1HL51971, NIGMS P20GM104357 and NIGMS U54GM115428This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.