Abstract
BackgroundThe purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status.Methodology/Principal FindingsThree single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption.ConclusionG allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
Highlights
Oral cancer is lethal and usually causes spacious impairment to the organs involved including lesions of lip, tongue, major salivary glands, gums and adjacent oral cavity tissues, floor of the mouth, tonsils, oropharynx, nasopharynx, hypopharynx and other oral regions, nasal cavity, accessory sinuses, middle ear, and larynx [1]
People with G/G homozygotes or with G/C heterozygotes of mammary serine protease inhibitor (Maspin) rs2289520 G/C polymorphism had a 2.07-fold and a 2.01-fold risk of developing oral cancer compared to those with C/C homozygotes after adjusting confound factors
Gene-to-gene interaction effect on the increased susceptibility to oral cancer was found, the adjusted odd ratios and 95% confidence intervals increased to a 2.46-fold and 2.61-fold risk of Variable Gender Male Female Tobacco consumption No Yes Alcohol consumption No Yes Areca consumption No Yes Age ≦53 >53
Summary
Oral cancer is lethal and usually causes spacious impairment to the organs involved including lesions of lip, tongue, major salivary glands, gums and adjacent oral cavity tissues, floor of the mouth, tonsils, oropharynx, nasopharynx, hypopharynx and other oral regions, nasal cavity, accessory sinuses, middle ear, and larynx [1]. It was reported that a absent expression of Maspin in tumor cells was significantly positive correlation with lymph node metastasis and invasive progression of OSCC, and patients with high levels of Maspin expression had better survival rates compared to those with low expressions of Maspin [4, 5, 7]. Shpitzer et al found that the level of Maspin in saliva was significantly decreased among patients with tongue cancer, they suggested detecting salivary Maspin level for diagnosis, prognosis, and post-operative monitoring of oral cancer [10]. The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status
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