Impact of low lymphocyte-to-monocyte ratio on prognosis in patients with acute ST segment elevation myocardial infarction after primary percutaneous coronary intervention

Abstract

Objective To evaluate the impact of lymphocyte-to-monocyte ratio(LMR)on long-term prognosis in patients with acute ST segment elevation myocardial infarction(STEMI)after primary percutaneous coronary intervention(PPCI). Methods A total of 282 STEMI patients who underwent PPCI were retrospectively analyzed in this study, and divided into LMR-increased group(LMR>2.3)and LMR-reduced group(LMR≤2.3)according to the ratio of LMR measured during hospitalization after PPCI.The incidence of major adverse cardiac events(MACE)including cardiac death, nonfatal myocardial infarction and revascularization was compared in two groups at 12 months follow-up after PPCI. Results Increased LMR was found in 102 patients(35.4%). White blood cells count(WBC), high-sensitivity C reactive protein(hs-CRP)and troponin I(TnI)levels was significantly higher in increased LMR group compared with decreased LMR group(P 0.05). MACE in increased LMR group significantly lower compared with decreased LMR group after 12 months follow up(4.9% vs. 13.4%, P<0.05). Multiple Logistic regression analysis showed low LMR, DM, culprit vessel of left descending artery(LAD)were the risk factors for poor prognosis. Conclusions Low LMR is a predicting risk factor for long-term poor prognosis in patients with STEMI after PPCI. Key words: Coronary artery disease; Angioplasty, transluminal percutaneous coronary; Prognosis; Lymphocyte-to-monocyte ratio