Abstract

The current study evaluated the effect of chronic consumption of saccharin and cyclamate on biochemical parameters in healthy individuals and patients with type 2 diabetes mellitus. Methods: Healthy and diabetic participants were classified into 2 groups based on whether they consumed sweeteners or not. The volunteers were also classified according to the amount of sweetener consumed per day (<5, 5-10, and >10 tablets) and according to the duration of sweetener consumption (<5, 5-10 and >10 years). The parameters measured were antioxidant parameters - serum catalase activity and serum peroxynitrite as well as pro-oxidant parameters - serum ceruloplasmin and the oxidation product - malondialdehyde. Glycated hemoglobin, fasting serum glucose, serum creatinine, alanine transaminase activity and lipid profile were also evaluated. Results: Saccharin and cyclamate increased levels of HbA1C, MDA, TG, LDL and TC/HDL by 11.16%, 52.38%, 16.74%, 13.39% and 13.11%, respectively, in healthy volunteers. Diabetic patients consuming sweetener showed increased levels of FSG, ceruloplasmin and MDA by 17.51%, 13.17% and 8.92%, respectively. Diabetic patients showed a positive correlation between the number of tablets consumed per day with FSG (r= 0.217, p=0.042) and serum creatinine (r= 0.267, p= 0.012). A positive correlation was found between the duration of sweetener consumption and FSG (r= 0.22, p=0.04) as well as TG (r= 0.262, p= 0.014). Conclusion: consumption of saccharin and cyclamate affected biochemical parameters related to metabolic function in a time and dose dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients.

Highlights

  • Previous studies conducted on saccharin and cyclamate were either limited to experimental animals or lacking evaluation of their long term consumption effects in humans

  • Subjects and Methods: The current study evaluated the effect of chronic consumption of tablets containing a This cross-sectional study was carried out between July 2015 to October 2016 at the Diabetic mixture of saccharin and cyclamate on biochemical parameters in healthy individuals and Center in Duhok, Kurdistan Regional Government - Iraq

  • Consumption of the saccharin and cyclamate tablets mixture affected biochemical parameters related to metabolic function in a time and dose dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients

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Summary

Introduction

Previous studies conducted on saccharin and cyclamate were either limited to experimental animals or lacking evaluation of their long term consumption effects in humans. With increased consumer interest in reducing sugar intake, food products made with sweeteners rather than sugar have become more common. In addition to individuals concerned about their diet, are more likely to use sugar-free and low-calorie products to reduce calorie consumption and control blood glucose levels. Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their use. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health

Objectives
Conclusion

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