Abstract
The physiologically important relationship between oxygen saturation and blood flow is not entirely understood, particularly with regard to the multiple velocity components of flow and temperature. While our previous studies used classic laser Doppler flowmetry combined with an enhanced perfusion probe to assess local blood flow following thermal stimulation, oxygen saturation signals were not assessed. Thus, the current study used multiscale entropy (MSE) and multiscale fuzzy entropy (MFE) to measure the complexity of oxygen saturation signals following thermal stimulation in healthy subjects. The results indicate that thermal stimulation increases oxygen saturation and affects the measured signal complexity in a temperature-dependent fashion. Furthermore, stimulus temperature not only affects the correlation between speed-resolved blood perfusion and oxygen saturation, but also the correlation between the complexity area indices (CAI) of the two signals. These results reflect the complexity of local regulation and adaptation processes in response to stimuli at different temperatures.
Highlights
The physiologically important relationship between oxygen saturation and blood flow is not entirely understood, with regard to the multiple velocity components of flow and temperature
Oxygen saturation arises from a dynamic balance between O2 supply and consumption in capillary, arteriolar, and venular beds and it is generally believed that local oxygen saturation is closely related to blood perfusion[8]
Building upon our previous study[10], which measured speed-resolved blood perfusion using the Enhanced Perfusion and Oxygen Saturation (EPOS) system, the present study combined these measurements with a simultaneous analysis of the changes in the complexity of oxygen saturation signals in response to thermal stimuli to clarify the relationship between oxygen saturation and speed-resolved blood perfusion
Summary
The physiologically important relationship between oxygen saturation and blood flow is not entirely understood, with regard to the multiple velocity components of flow and temperature. Stimulus temperature affects the correlation between speed-resolved blood perfusion and oxygen saturation, and the correlation between the complexity area indices (CAI) of the two signals These results reflect the complexity of local regulation and adaptation processes in response to stimuli at different temperatures. By integrating diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) into a single fiber-optic probe, the Enhanced Perfusion and Oxygen Saturation (EPOS) system can measure blood flow and blood oxygen saturation simultaneously[5]. This new method may provide further insight into vascular dysfunction at both local and systemic levels[6,7]. Relevant research shows that MFE has a more significant correlation with MSE than other multiscale entropies[19]
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