Abstract
Genetic variant LMP7 (low molecular weight polypeptide 7) –145 C > A may influence the function of immune surveillance of an individual and lead to cancer development. Various studies have investigated the relevance of LMP7 –145 C > A gene polymorphism with cancer risk; but, their results are conflicting and inconsistent. To obtain a comprehensive conclusion, a meta-analysis was performed by including eight eligible published studies retrieved from PubMed (Medline), EMBASE and Google Scholar web search until December 2016. Individuals with AA genotype (AA vs CC: p = 0.001; OR = 2.602, 95% CI = 1.780 to 3.803) of LMP7 -145 C > A were found to have 2 folds higher risk of cancer than those with CC genotype. The recessive genetic model (AA vs AC + CC) also indicated that individuals with AA genotype have 2 folds higher cancer risk than AC and CC genotypes (p = 0.001; OR = 2.216, 95% CI = 1.525 to 3.221). Also, significant increased cancer risk was observed in Asians but not in Caucasians. No publication bias was observed during the analysis. Trial sequential analysis also strengthened our current findings. These results suggest that genetic variant LMP7–145 C > A has significant role in increasing cancer risk in overall and Asian population, and could be useful as a prognostic marker for early cancer predisposition.
Highlights
Cancer is one of the ever dreadful disease, and a leading cause of death, and a severe public health problem worldwide [1]
Trial sequential analysis strengthened our current findings. These results suggest that genetic variant LMP7–145 C > A has significant role in increasing cancer risk in overall and Asian population, and could be useful as a prognostic marker for early cancer predisposition
The confounding conclusions from previous studies regarding the role of LMP7–145 (C > A) gene polymorphism as genetic marker for cancer susceptibility and progression [20,21,22,23,24,25,26,27] impelled us to perform their metaanalysis in order to understand the precise association between this polymorphism and cancer risk
Summary
Cancer is one of the ever dreadful disease, and a leading cause of death, and a severe public health problem worldwide [1]. Various projection based studies reported that the worldwide burden of cancer will rise more rapidly with rising population, aging and changes in the lifestyle [2]. It is predicted that there will be more than 20 million new cancer cases globally by the year 2025 [3]. The growing number of studies reported that the initiation of www.impactjournals.com/oncotarget cancer is a complex process that includes the results of genetic susceptibility and various environmental factors [4]. The identification of genetic risk factors that contribute to the substantial burden of the disease in general population is warranted for the development of broad therapeutic strategies for cancer prevention
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
