Impact of knee OA on meeting physical activity guidelines

Abstract

s / Osteoarthritis and Cartilage 23 (2015) A17eA25 A18 with any therapeutic candidate development paradigm, toxicologic and safety pharmacology evaluations should indicate a low level of risk associated with dosing and administration procedures, thereby enhancing the rationale for investing in such a modality for the treatment of OA. I-3 IMPACT OF KNEE OA ON MEETING PHYSICAL ACTIVITY GUIDELINES D.K. White. Univ. of Delaware, Newark, DE, USA Purpose: Physical activity has irrefutable health benefits. For people with knee osteoarthritis (OA), pain is a well-known cause of functional limitation in people with knee (OA), however it is unclear whether it is also responsible for a reduction in physical activity behaviors. Anecdotally, pain is thought to be responsible for less physical activity. We will review the literature investigating whether knee OA-related pain is in fact a risk factor for less physical activity. As well, we will investigate whether physical activity is responsible for changes in pain. Methods: We will summarize studies of objectively measured physical activity among people with knee OA from well-established cohort studies. We will also review the association of physical activity with knee pain and function from clinical intervention trials and observational studies among people with knee OA. Results: Physical activity guidelines, i.e., participation in at least 150 minutes of moderate to vigorous physical activity (MVPA), was met by 12.9% of men and 7.7% of women from the Osteoarthritis initiative. However, a similarly low proportion met guidelines from the National Health and Nutrition Examination Survey. Furthermore, a similar proportion of people with and without knee pain met guidelines from daily walking from the Multicenter Osteoarthritis (MOST) study. These data suggest the presence of knee painmay not fully account for low levels of physical activity in knee OA. Clinical trials incorporating physical activity interventions, such as aerobic walking, reduce knee pain. We have previously reported a strong association between walking at least 6,000 steps/day and the prevention of functional limitation 2 years later in the MOST study. Conclusions: Knee pain alone may not lead to a reduction in physical activity among people with knee OA. However, the benefits of adopting a physically active lifestyle include reducing existing knee pain and preventing the development of functional limitation in knee OA. I-4 THE AGING PROCESS AND EPIGENETICS: RELATIONSHIP WITH OA L. Reynard. Inst. of Cellular Med., Newcastle Univ., Newcastle upon Tyne,