Impact of joint hypermobility syndrome on gastric accommodation and nutrient tolerance in functional dyspepsia.

Abstract

FD patients filled out a dyspepsia symptom severity score. Intragastric pressure (IGP) was measured with high-resolution manometry (HRM) during the intragastric infusion of nutrition drink (ND, 1.5Kcal/ml, 60ml/min) until maximal satiation in healthy subjects and FD. We compared IGP profiles and nutrient tolerance in HS and FD with or without JHS. JHS was present in 54% of FD patients (n=39, 41.2±2.2years old) and 7% of healthy subjects (n=15, 27.3±2.3years old). IGP drop and nutrient tolerance were lower in non-JHS-FD compared with JHS-FD and HS (AUC JHS-FD: -17.9±2.5 vs. non-JHS-FD: -13.0±3.3mmHgmin, p=0.2, HS:-19.6±2.9mmHgmin; ND tolerance non-JHS-FD: 671.0±96.0 vs. JHS-FD: 842.7±105.7Kcal, p=0.25, HS: 980.0±108.1Kcal). JHS often co-exists with FD. Non-JHS-FD was characterized by decreased accommodation and lower nutrient tolerance characterized compared with JHS-FD. Clinicaltrials.gov, reference number NCT04279990.