Impact of intracamerular Cefuroxime on post‐operative endophthalmitis in Languedoc Roussillon, France from 2010 to 2014

Abstract

PurposePost‐operative endophthalmitis remains the most severe complication of cataract surgery. The purpose of this study was to determine the incidence of post‐operative endophthalmitis in Languedoc Roussillon between 2010 and 2014. Secondary objective was to assess the correlation between the use of intracamerular injection of cefuroxime and post‐operative endophthalmitis incidence.MethodsAll patients >40 years old who underwent a primary cataract surgery in Languedoc Roussillon (France) between January 2010 and December 2014 were collected from the regional administrative database of medical care. Incidence rate of post‐operative endophthalmitis was estimated. Spearman coefficient was used to assess the correlation between the incidence of post‐operative endophthalmitis and the use of intracamerular cefuroxime at the end of cataract surgery.ResultsIn 5 years, 179 515 eyes underwent a cataract surgery in Languedoc Roussillon. A total of 182 patients had a post‐operative endophthalmitis owing to a 1 year incidence of 0.10% after cataract surgery. The incidence of endophthalmitis decreased over the study: 0.16%, 0.12%, 0.11%, 0.07% and 0.05% in 2010, 2011, 2012, 2013 and 2014, respectively. The use of cefuroxime prophylactic injection at the end of cataract surgery increased over the study: 3.27%, 7.65%, 32.04%, 75.67% and 85.36% in 2010, 2011, 2012, 2013 and 2014, respectively. The incidence of post‐operative endophthalmitis was negatively correlated with the use of intracamerular injection of cefuroxime (r = −0.96, p = 0.008).ConclusionsThis study provides information on the decrease of post‐operative endophthalmitis incidence and its correlation with the increased use of cefuroxime intracamerular injection to prevent the risk of infection in the real world. This observational study confirms the promising results of the ESCRS study.