IMPACT OF INTERFERON-CONTAINING DRUGS ON PRO- AND ANTIOXIDANT STATUS IN NEWBORN PIGLETS

Abstract

The article presents the results of studies on the impact of biferon-S, containing recombinant porcine interferons alpha and gamma, and prostimul, which contains a recombinant type I cytokine and vitamins A, E and C, on the pro- and antioxidant status of piglets under conditions of an industrial pig breeding complex. It has been found that the use of drugs for the newborn piglets helps to reduce the lipid peroxidation and endogenous intoxication, manifested by a decrease in the number of malondialdehyde, peptides of medium molecular weight and indicators of endogenous intoxication. This also contributes to a decrease in the number of stable nitric oxide metabolites involved into the oxidative stress reactions and an increase in the activity of antioxidant enzymes. A more essential positive effect on the LPO-AOD system in piglets has been exerted by prostimul, which, in addition to the type I cytokine, contains vitamins A, E and C. They increase the antioxidant status of the body, enhancing the antioxidant activity of the blood plasma, protecting the cells of the immune system from oxygen-dependent types of apoptosis, they potentiate the efficacy of interferons as well.