Abstract
BackgroundFew prospective studies have explored the effect of interactions among metabolic syndrome (MS) components on the development of cardiovascular disease (CVD) in the Kazakh population in Xinjiang Province of China.MethodAs of December 2016, 2,644 participants who completed a baseline survey over a period of 5 years or more were included in the study. The multiplicative interactions among MS components were evaluated by incorporation of the product terms into a logistic regression model. The additive interactions among MS components were evaluated by calculating the additive interaction index. Logistic regression was used to construct a predictive model, and CVD risk level was divided according to the risk probability of the population that did not eventually have CVD.ResultsWhen we analyzed the independent risk of MS and its components on developing CVD, only blood pressure(BP) and waist circumference(WC) were associated with CVD. A linear association was found between the risk of CVD, BP/WC, and the number of other components (trend, P<0.001). The risk of developing CVD increased when BP and WC coexisted, or when combined BP/WC with MS (≥3 components except for BP and WC) was present; however, there were no significant interactions among MS components. After the CVD hazards were divided into four levels, it was showed that over 19.92% of the incidence probability was in the population under mediate-risk while over 35.24% of them was in the high-risk group, respectively.ConclusionsBP and WC were independent risk factors for CVD in the Kazakh population. The risk of CVD was greatly increased when BP and WC coexisted or when combined BP/WC with MS (≥3 components except for BP and WC) was present, but no significant interactions were found among MS components.
Highlights
Cardiovascular disease (CVD) accounts for about 40% of all deaths in China and creates a vast economic burden[1]
After the CVD hazards were divided into four levels, it was showed that over 19.92% of the incidence probability was in the population under mediate-risk while over 35.24% of them was in the high-risk group, respectively
The risk of CVD was greatly increased when BP and WC coexisted or when combined BP/WC with metabolic syndrome (MS) ( 3 components except for BP and WC) was present, but no significant interactions were found among MS components
Summary
Cardiovascular disease (CVD) accounts for about 40% of all deaths in China and creates a vast economic burden[1]. Numerous studies have shown that patients diagnosed with metabolic syndrome(MS)are more likely to have or develop CVD[2,3,4,5,6,7]. Liu et al.[9] found that BP and other MS components are only independent of each other for CVD, and there is no obvious interaction when these risk factors coexist. Both studies explored the interactions among MS components, but it is only the interaction between BP and other MS components. Few prospective studies have explored the effect of interactions among metabolic syndrome (MS) components on the development of cardiovascular disease (CVD) in the Kazakh population in Xinjiang Province of China
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