Abstract
Objective:Insulin-like growth factor 2 had a high expression in many cancers.In the current paper,the expression of Insulin-like growth factor 2 was investigated and its prognostic significance in lung adenocarcinoma with mediastinal lymph node metastasis was studied.Methods:A retrospective immunohistological analysis of specimens of lung adenocarcinoma with mediastinal lymphnode metastasis was conducted.All patients did not have neoadjuvant chemotherapy and/or radiotherapy.The prognostic factors of stage N_2 lung adenocarcinoma and the impact of insulin-like growth factor 2 on the prognosis of patients with stage N_2 lung adenocarcinoma were also studied.Results:Factors including T stage,station 7 metastasis,and the number of metastatic stations had an impact on the prognosis of stage N2 lung adenocarcinoma.The 5-year overall survival of patients with negative and positive expression of insulin-like growth factor 2 were 18%and 8%,respectively(P= 0.034 ).Conclusion:The prognosis of stage N_2 lung adenocarcinoma is poor.The prognostic factors of stage N_2 lung adenocarcinoma include the T stage,station 7 metastasis,the number of metastatic stations,and the expression of insulin-like growth factor 2.
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