Abstract
The intrabone (IB) route of stem cell administration results in improved engraftment in murine models of transplantation. However, human clinical trials have yet to establish that hematopoietic stem cell (HSC) engraftment is improved with the use of IB delivery. The use of IB vascular access can rapidly restore systemic blood volume and pressure in shock situations, although this access route can be associated with pulmonary emboli. Furthermore, both pressure and shear stress, which have not been characterized with conventional IB delivery techniques, may damage HSCs compromising their ability to engraft.
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