Abstract
Abstract Background Nonsurgical septal reduction therapy (NSRT) with ethanol improves clinical and hemodynamic parameters in patients with symptomatic hypertrophic obstructive cardiomyopathy. The purpose of this study was to examine the impact of infarct size induced by ethanol injection on clinical and echocardiographic outcome after the procedure. Methods and results The first 261 consecutive patients were included. The mean age was 51 ± 6 years, and 127 patients were women. The mean creatine kinase (CK) after NSRT was 1411 ± 653 units. Men had larger infarcts than women ( P = .0028). Injecting ethanol as a bolus ( P 1 septal branch ( P 3 cc of ethanol per septal branch ( P 1000 U/dL compared to those with peak CK 1500 U/dL had a significant drop in left ventricular ejection fraction at 6 weeks (70 ± 6 vs 63 ± 6, P = .035). Conclusion An average size infarct (peak CK 1000–1500 U/dL) seems to lead to the optimal outcome after NSRT.
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