Abstract
Inflammatory bowel diseases (IBD) belong to the group of immune-mediated diseases (IMIDs). The effect of associated IMIDs in the prognosis in IBD is nowadays unknown. To describe IMIDs associated to IBD patients and evaluate differences linked to the presence or absence of IMIDs. A unicentric retrospective descriptive study was designed. A cohort of 1,448 patients were categorized according to the presence of IMIDs. Clinical characteristics were obtained from IBD database. Univariate and multivariate analysis were performed. 385 patients were diagnosed with associated IMIDs while 1,063 had no associated IMIDs. A prevalence of 26.6% IMIDs associated to IBD was observed. Asthma, skin psoriasis and rheumatoid diseases were most commonly found. Factors associated to the presence of IMIDs were women (OR 1.48; 95 CI 1.17–1.87) and Crohn’s disease (OR 1.35; 95 CI 1.07–1.70). Patients with associated IMIDs required more immunomodulator (OR 1.61; 95 CI 1.27–2.43) and biological treatment (OR 1.81; 95 CI 1.47–2.43). More surgical risk was observed in multivariate analysis in those patients diagnosed with IMIDs prior to the onset of IBD (OR 3.71; 95% CI 2.1–6.56). We considered the presence of IMIDs a poor prognostic factor and suggest a closer monitoring of these patients.
Highlights
Inflammatory bowel diseases (IBD) belong to the group of immune-mediated diseases (IMIDs)
An observational study of cohorts was performed to describe the influence of IMIDs in IBD, their implication in the progression of the disease and available treatments
We observed a prevalence of IMIDs of 26.6%, higher than the prevalence described in previous studies conducted in different geographical a reas[26,27,28]
Summary
Inflammatory bowel diseases (IBD) belong to the group of immune-mediated diseases (IMIDs). Abbreviations IMIDs Immune-mediated diseases IBD Inflammatory bowel disease ECCO European Crohn’s ad Colitis Organisation APC Antigen presenting cells TH1 T helper lymphocytes type 1 TH2 T helper lymphocytes type 2 TNF-α Tumor necrosis factor alpha IL Interleukin GP General practitioners SD Standard deviation OR Odds ratio. Immune mediated diseases (IMIDs) are a group of autoimmune inflammatory disorders characterized by an alteration in cellular h omeostasis[1]. The etiology of these diseases is multifactorial including environmental factors, dietary habits and infectious agents in patients with a genetic predisposition[2]. Once an antigen in IMIDs initiates the inflammatory response, a higher production of pro-inflammatory cytokines is observed as TNF-α, IL-1, IL-6 and the reduction of other cytokines such as IL-10 and IL-48,9
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