Impact of immune effect to different dosage hepatitis B virus vaccine in premature infants.

Abstract

Objective To investigate the strong or weak impact of immune response to different pregnant week premature infants in different dosage hepatitis B virus vaccine and the level changes of immune response rate, anti-hepatitis b surface(HBs) titer, Immunoglobulin (IgG, IgM, IgA) and complement (C)3,C4. Methods From April 2009 to October 2010, 270 case o f premature and 100 cases of healthy full-term infants were recruited in the newborn department. Those cases were divided into 4 groups: 30 pregnant weeks ( group Ⅰ, n=90), pregnant weeks from 30 to 33 weeks (group Ⅱ, n=90); pregnant weeks from 34 to 36 (group Ⅲ, n=90); pregnant weeks 37 weeks (cont rol group, n=100). Then every group was sub-divided into group A(5 μg HB Vaccine) and group B (10 μg HB Vaccine) according to inoculation dose, the time of inoculation is at the 0, 1st and 6th month after birth . The anti-HBstiters, concentration of immunoglobulin (IgG, IgM, IgA) and comp lement (C3, C4) after four months from the third inoculation were examined. The newborns were injected 200 IU HBIG in 12 hours after the birth if his mother w as hepatitis B virus carrier. Strong or weak response rates of hepatitis B vacc ine in each group and the differences of seroconversion rate were compared. The chan ges of strong and weak response in immunoglobulin levels were analyzed. Results No obvious local and systemic reaction was found in all groups and all tests were finished successfully. No significant differences of anti-HBs titer were found among group of Ⅰ-A, Ⅱ-A, Ⅲ-A and control group A ( P0.05), also among groupⅠ-B, Ⅱ-B, Ⅲ-B and control group B (P 0.0 5). Statistically significant differences of anti-HBs strong response percent age were found amongⅠ-A, Ⅱ-A, Ⅲ-A and control group A (P0.05); also a mong groupⅠ-B, Ⅱ-B, Ⅲ-B and control group B (P0.05). Immunoglobulin ( IgG, IgM, IgA) and complement (C3, C4) changes: Ⅰ, Ⅱ, Ⅲ and control gro ups were compared in A, and B groups, IgM, IgA, C3 strong response level signifi cantly higher than no (weak) response level of premature infants (P0.05); Group B of hepatitis B vaccine seroconversion rate was significantly higher than that of group A (P0.05). Conclusions Premature infants with hepatitis Bvaccine after birth did not find any adverse reaction, and the an tibody levels generate better. Stronger response percentage of premature infants is lower than that of full-term infants, especially 30 pregnant-week premat ureinfants. High-dose hepatitis B vaccine can improve the strong response percentage of premature hepatitis B vaccination. Premature infants with strong responses have better humoral immune function than infants without or weak response.