Impact of image preprocessing methods on reproducibility of radiomic features in multimodal magnetic resonance imaging in glioblastoma

Hajar Moradmand,Seyed Mahmoud Reza Aghamiri,Reza Ghaderi

doi:10.1002/acm2.12795

Hajar Moradmand, Seyed Mahmoud Reza Aghamiri + Show 1 more

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https://doi.org/10.1002/acm2.12795

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Abstract

To investigate the effect of image preprocessing, in respect to intensity inhomogeneity correction and noise filtering, on the robustness and reproducibility of the radiomics features extracted from the Glioblastoma (GBM) tumor in multimodal MR images (mMRI). In this study, for each patient 1461 radiomics features were extracted from GBM subregions (i.e., edema, necrosis, enhancement, and tumor) of mMRI (i.e., FLAIR, T1, T1C, and T2) volumes for five preprocessing combinations (in total 116 880 radiomics features). The robustness and reproducibility of the radiomics features were assessed under four comparisons: (a) Baseline versus modified bias field; (b) Baseline versus modified bias field followed by noise filtering; (c) Baseline versus modified noise, and (d) Baseline versus modified noise followed bias field correction. The concordance correlation coefficient (CCC), dynamic range (DR), and interclass correlation coefficient (ICC) were used as metrics. Shape features and subsequently, local binary pattern (LBP) filtered images were highly stable and reproducible against bias field correction and noise filtering in all measurements. In all MRI modalities, necrosis regions (NC: n ® ~449/1461, 30%) had the highest number of highly robust features, with CCC and DR >= 0.9, in comparison with edema (ED: n ® ~296/1461, 20%), enhanced (EN: n ® ~ 281/1461, 19%) and active‐tumor regions (TM: n ® ~254/1461, 17%). The necrosis regions (NC: n¯ ~ 449/1461, 30%) had a higher number of highly robust features (CCC and DR >= 0.9) than edema (ED: n¯ ~ 296/1461, 20%), enhanced (EN: n¯ ~ 281/1461, 19%) and active‐tumor (TM: n¯ ~ 254/1461, 17%) regions across all modalities. Furthermore, our results identified that the percentage of high reproducible features with ICC >= 0.9 after bias field correction (23.2%), and bias field correction followed by noise filtering (22.4%) were higher in contrast with noise smoothing and also noise smoothing follow by bias correction. These preliminary findings imply that preprocessing sequences can also have a significant impact on the robustness and reproducibility of mMRI‐based radiomics features and identification of generalizable and consistent preprocessing algorithms is a pivotal step before imposing radiomics biomarkers into the clinic for GBM patients.

Highlights

Glioblastoma (GBM) is the most aggressive malignant type of brain tumor, commonly occurs
The effect of Magnetic resonance imaging (MRI) image preprocessing including or excluding intensity inhomogeneity correction and noise filtering on the reproducibility of the radiomics features was evaluated by four comparisons as follows: (a) Baseline versus modified bias field; (b) Baseline versus modified bias field followed by noise filtering; (c) Baseline versus modified noise reduction, and (d) Baseline versus modified noise followed bias field correction
For each patient 1,461 radiomics features were extracted from GBM sub‐regions of multimodal MR images (mMRI) (i.e., fluid‐attenuated inversion recovery (FLAIR), T1, T1C, and T2) volumes for five preprocessing combinations

Summary

Introduction

Glioblastoma (GBM) is the most aggressive malignant type of brain tumor, commonly occurs (de novo). There is arisen interest to characterize tumor heterogeneous and phenotypes based on the high‐throughput quantified features extracted from the clinical standard of care image for providing image‐based biomarkers relating to the pathologic, genomic, proteomic, and clinical data, which is wellknown as radiomics.[2]. The main issue and challenging for the clinical applicability of the radiomics is the reliability and repeatability of the radiomics features[4] across multi‐centers. Reliability and reproducibility can be affected by various aspects of radiomics processing (e.g., image acquisition parameters and protocols, image preprocessing algorithms, tumor segmentation, and software used for processing and feature extractions). Major of radiomics studies by concerning a different aspect of radiomics reproducibility and repeatability issue was done in computed tomography (CT) and PET modalities for limited cancer types,[5,6] and a few studies have been reported in MRI.[7]

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