Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia"

Abstract

We thank Dr. Qazi and Dr. Uckun for their letter that focused on the biological relevance of IKZF1 deletions in pediatric acute lymphoblastic leukemia (ALL), and in particular on the lack of correlation between IKZF1 deletions and the expected deregulation of IKZF1 expression. This information