Abstract
Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425-A1g8
Highlights
With the majority of HIV infections resulting from mucosal transmission of HIV, induction of an effective mucosal immune response would be pivotal in preventing transmission
The monoclonal antibody F425-A1g8 was generated in our laboratory by hybridoma technique and showed binding activity to the CD4i site of gp120
This research clearly suggests that IgA isotype utilizing its unique molecular structure plays an important role in HIV neutralization
Summary
With the majority of HIV infections resulting from mucosal transmission of HIV, induction of an effective mucosal immune response would be pivotal in preventing transmission. Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425-A1g8 X Yu1*, M Duval2, C Lewis2, L Cavacini1
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