Abstract
Despite advances in medicine, aortic diseases (ADs) such as aortic dissection and aortic aneurysm rupture remain fatal with extremely high mortality rates. Owing to the relatively low prevalence of AD, the risk of AD-related death has not yet been elucidated. The aim of the present study was to examine whether hyperuricemia is a risk factor for AD-related mortality in the general population. We used a nationwide database of 474,725 subjects (age 40–75 years) who participated in the annual “Specific Health Check and Guidance in Japan” between 2008 and 2013. There were 115 deaths from aortic dissection and aortic aneurysm rupture during the follow-up period of 1,803,955 person-years. Kaplan–Meier analysis revealed that subjects with hyperuricemia had a higher rate of AD-related death than those without hyperuricemia. Multivariate Cox proportional hazard regression analysis demonstrated that hyperuricemia was an independent risk factor for AD-related death in the general population. The net reclassification index was improved by addition of hyperuricemia to the baseline model. This is the first report to demonstrate that hyperuricemia is a risk factor for AD-related death, indicating that hyperuricemia could be a crucial risk for AD-related death in the general population.
Highlights
IntroductionAortic diseases (ADs) such as aortic dissection and aortic aneurysm rupture remain fatal with extremely high mortality rates
Despite advances in medicine, aortic diseases (ADs) such as aortic dissection and aortic aneurysm rupture remain fatal with extremely high mortality rates
Kaplan–Meier analysis demonstrated that subjects with hyperuricemia had a higher rate of AD-related death than those without hyperuricemia (Fig. 1)
Summary
Aortic diseases (ADs) such as aortic dissection and aortic aneurysm rupture remain fatal with extremely high mortality rates. The aim of the present study was to examine whether hyperuricemia is a risk factor for AD-related mortality in the general population. Patients with aortic diseases (ADs), such as aortic dissection and aortic aneurysm rupture, reportedly had higher levels of uric acid than those without ADs9–11, the impact of hyperuricemia on AD-related mortality in the general population remains undetermined. Because the prevalence of AD is relatively low, there has been no prospective cohort study with sufficient data to analyze whether hyperuricemia could be a risk factor for AD in the general population until now. The present study aimed to examine whether hyperuricemia is a pivotal risk factor for AD-related death in the general population. BMI body mass index, eGFR estimated glomerular filtration rate, HbA1c glycosylated hemoglobin A1c
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
