Abstract
Background: Hypoglossal motor nucleus (HN) controls the movement of genioglossus (GG) muscle which results in airway occlusion and the occurrence of obstructive sleep apnea (OSA). Histamine produced by tuberomammillary nucleus (TMN) has a potent excitatory action on GG muscle activity. Methods: C57BL/6 mice were exposed to CIH for 3 weeks to resemble OSA. The histamine H3 receptor (H3R) antagonist ciproxifan was applied to increase histamine in brain. Level of histamine and GG activity were measured. Neuronal activity and repair ability of HN and TMN were analyzed. Results: Significant decline of histamine and GG activity and severe damage of neuronal activity and repair ability of HN and TMN induced by CIH could be ameliorated by ciproxifan. Conclusion: This investigation studied the impacts of ciproxifan on HN and TMN in CIH condition and revealed that negative effects on HN and TMN caused by CIH could be partly ameliorated by ciproxifan, which might open new perspectives for the development of pharmacological treatments for OSA.
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