Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia.

Jocelyn Turpin,Aviva Witkover,Damian Purcell,David Yurick,Hai Pham,Charles R M Bangham,Anat Melamed,Lloyd Einsiedel,Georges Khoury,Stephen Locarnini,Kim Wilson

doi:10.1093/infdis/jiy546

Abstract

The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1-associated malignant disease.

Highlights

To cite this version: Jocelyn Turpin, David Yurick, Georges Khoury, Hai Pham, Stephen Locarnini, et al
The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described
All Indigenous adults (>18 years old) presenting to Alice Springs Hospital (ASH) and found to be hepatitis B surface antigen (HBsAg) positive were eligible for recruitment

Summary

Introduction

To cite this version: Jocelyn Turpin, David Yurick, Georges Khoury, Hai Pham, Stephen Locarnini, et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1–infected lymphocytes in coinfected asymptomatic individuals. We conclude that HTLV-1/ HBV coinfection may predispose to HTLV-1–associated malignant disease

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