Abstract
The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value<0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value<0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.
Highlights
Salivary duct carcinoma (SDC) arises from the ductal epithelium of the salivary gland and accounts for approximately 10% of all salivary gland malignancies [1, 2]
The 3-year overall survival (OS) among all patients was 65.5% (95% confidence interval (CI), 56.6–72.9), and 3-year progression-free survival (PFS) was 32.0%
We found significant association of high neutrophilto-lymphocyte ratio (NLR) (≥2.5) with OS (HR 1.80; 95% CI, 1.05-3.08; p-value=0.032), this association was inconsistent with the results of PFS
Summary
Salivary duct carcinoma (SDC) arises from the ductal epithelium of the salivary gland and accounts for approximately 10% of all salivary gland malignancies [1, 2]. Recent studies have described the impact of several hematological inflammatory and nutritional markers on survival in a number of cancers, including head and neck cancer (HNC) These markers include the Glasgow prognostic score (GPS) or modified Glasgow prognostic score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44]. The association between these factors and SDC survival has not been reported
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