Abstract
BackgroundGestational diabetes mellitus is the most common metabolic dysfunction that arises during pregnancy. GDM can lead to serious health complications for both the mother during pregnancy and after the delivery of the baby. Additionally, mother–offspring suffers from abnormalities in metabolism. The study aimed to investigate glutathione S‑transferase P1 and ghrelin genetic variants in pregnant women diagnosed with gestational diabetes using a tetra-primer amplification refractory mutation system.ResultsThis study demonstrated that the frequencies of genotypes in women with GDM were GSTP1-AG (87.1%) and GHRL-GG (100%). The study revealed no significant differences in the frequency of either genotype or allele of both GSTP1 and ghrelin between GDM and healthy pregnant women.ConclusionsThis study may be the first study designed to demonstrate that there is no association between the genotype and allele frequencies of GSTP1 (rs1695) and ghrelin (rs696217) in the development of gestational diabetes mellitus in Egyptian women.
Highlights
Gestational diabetes mellitus is the most common metabolic dysfunction that arises during preg‐ nancy
The study aimed to evaluate the single nucleotide polymorphisms (SNPs) in glutathione S-transferase P1 (A/G rs1695) and ghrelin (G/T rs696217) and correlate its genotyping to gestational diabetes mellitus. This may be the first study designed to reveal that there is no association between the genotype and allele frequencies of both Glutathione S-transferase P1 (GSTP1) and ghrelin in the development of gestational diabetes mellitus in Egyptian women
The data found that there was no significant difference in the mean age and body mass index (BMI) among women with gestational diabetes and healthy pregnant women
Summary
Gestational diabetes mellitus is the most common metabolic dysfunction that arises during preg‐ nancy. The study aimed to investigate glutathione S‐transferase P1 and ghrelin genetic variants in pregnant women diagnosed with gestational diabetes using a tetra-primer amplification refractory mutation system. Gestational diabetes mellitus (GDM) is the most common metabolic dysfunction of pregnant women detected in the second or third trimester of pregnancy. GDM can cause hyperglycemia, macrosomia, high blood pressure, preeclampsia, premature birth, and stillbirth at the end of pregnancy [2]. It is not caused by a lack of insulin but by Glutathione S-transferase P1 (GSTP1) gene maps on the long arm of chromosome 11, which is composed of seven exons. The glutathione S-transferases (GSTs) are isoenzyme superfamilies that detoxify toxic substances and protect macromolecules from reactive electrophiles, reactive oxygen species, chemotherapeutic agents, and environmental carcinogens [8]
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