Impact of gastrointestinal events on patient-reported outcomes in Asia-Pacific women with osteoporosis: baseline results of the MUSIC OS-AP study

A Modi,S Baidya,Y K Min,P R Ebeling,S Sen,X Yang,M S Lee,S Sajjan,A Mithal

doi:10.1007/s11657-017-0350-3

Abstract

SummaryThe purpose of this study was to describe the impact of gastrointestinal events on patient-reported outcomes and health care resource use among Asia-Pacific women with postmenopausal osteoporosis. The results of this study show that gastrointestinal events decreased adherence, treatment satisfaction, and quality of life in Asia-Pacific women with postmenopausal osteoporosis.PurposeThis study aimed to describe the impact of gastrointestinal (GI) events on patient-reported outcomes and health care resource use among Asia-Pacific women with postmenopausal osteoporosis.MethodsThe MUSIC OS-AP study included an observational cohort study of postmenopausal women with osteoporosis. Women were classified as untreated or treated, with treated patients further classified as new or experienced users. Adherence was measured by the Adherence Evaluation of Osteoporosis treatment (ADEOS) questionnaire, treatment satisfaction by the Osteoporosis Patient Satisfaction Questionnaire (OPSAT) while general health-related and osteoporosis-specific quality of life were measured by the European Quality of Life-5 Dimensions (EQ-5D) questionnaire and the Osteoporosis Assessment Questionnaire (OPAQ), respectively. The association of GI events with these outcomes was determined by covariate-adjusted regression analysis of least squares mean differences in the scores of treated patients with and without GI events. Resource utilization was measured as the number of physician visits over the past 3 months, and multivariate regression analysis was used to assess the association of GI events with the likelihood of a visit.ResultsThe GI event profile, quality of life scores, and resource use were numerically similar in untreated and treated women. The rate of adherence among treated women was higher in experienced than in new users. As indicated by mean scores, experienced users had better quality of life and slightly higher treatment satisfaction and fewer physician visits than new users. Except for adherence in new users, all measures were similarly adversely affected by GI events in both new and experienced users.ConclusionsGI events decreased adherence, treatment satisfaction, and quality of life in Asia-Pacific women with postmenopausal osteoporosis.

Highlights

The incidence of osteoporotic hip fracture has risen 2–3-fold in Asia over the past few decades [1]
The gastrointestinal (GI) events that are common among users of osteoporosis therapy in US [3] and European [4, 5] populations are virtually uncharacterized in patients in the Asia-Pacific region
Adherence was measured by the Adherence Evaluation of Osteoporosis treatment (ADEOS) questionnaire [18] and defined as a score of ≥20 out of 22

Summary

Introduction

The incidence of osteoporotic hip fracture has risen 2–3-fold in Asia over the past few decades [1]. The gastrointestinal (GI) events that are common among users of osteoporosis therapy in US [3] and European [4, 5] populations are virtually uncharacterized in patients in the Asia-Pacific region. Such events, or use of medications suggesting their occurrence, have been shown to be associated with reduced adherence (both compliance and persistence) to treatment [6,7,8,9,10,11] and low treatment satisfaction [12,13,14]. Such associations have not been assessed in Asian or Australian populations

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