IMPACT OF GALVANIZATION ON THE COURSE OF THE WOUND PROCESS IN THERMAL BURNS

Abstract

Resume. The aim of the research was to study the feasibility of galvanization in the case of superficial and deep dermal thermal burns.
 Materials and methods. The efficiency of the direct current electric field (DCEF) was studied in an experiment on 16 sexually mature white rats weighing from 190 to 250 g, by causing them thermal burns using a special device. The area of the simulated burn was 8–10 % of the rat body surface, depending on its size. The depth of the lesion corresponded to IIIA-B degree burns according to O. V. Vyshnevsky (superficial and deep dermal burns). Galvanization of the damaged area was performed under anesthesia from the 3rd day using the device «Stream-1» with a direct current density of 0.04–0.05 mA/cm2 for 30 minutes. Behavioral reactions of animals, dynamics of weight loss, features of the wound process in the area of thermal damage were evaluated. Histological and bacteriological examination of wounds was performed for 2–3, 6–7, 13–14, and 19–21 days after modeling of burns.
 Results and discussion. The use of galvanization of burn wounds contributed to the activation of demarcation and cleaning processes in the damaged area, accelerated reparative regeneration, reduced microbial contamination of the wound surface. Thus, the optimization of the wound process was achieved, which was reflected in the timing of healing of the affected areas.
 Conclusions. As a result of an experimental study, it was found that DCEF has a beneficial effect on the wound process in the case of superficial and deep dermal thermal burns.