Abstract
ObjectiveTo ascertain the haematological properties of aqueous extract of G. applanatum(G. applanatum). MethodsSixty albino rats were grouped into six equal groups (10 each) from A to F, consisting of tests and controls. Laboratory albino rats in groups A, B and C were infected with Trypanosoma brucei (T. brucei) while groups A and B (Test) were treated with aqueous G. applanatum extract; other groups served as control. Microscopy and haematological profiles from the albino rats were monitored on daily basis for blood parasites, Packed Cell Volume (PCV), Haemoglobin Concentration (HC), Total Red Blood Cell Count (RBC), Mean Cell Haemoglobin (MCH), Mean Cell Volume (MCV), Mean Cell Haemoglobin Concentration (MCHC), and Total White Blood Cell Count (WBC). ResultsAlbino rats in groups A, B and C infected with T. brucei and treated with various concentrations of aqueous G. applanatum showed a progressive reduction in PCV, HC, RBC, MCH and MCHC compared to the controls (P < 0.05). All the infected rats died by day 14 of the experiment from parasitaemia. ConclusionsG. applanatum lacks ability to boost haematological profiles of anaemic laboratory rats and also of no use in the treatment of African Trypanosomiasis. Higher doses of the fungal extract may be required to test on laboratory rats with less lethal biological stimulants of anaemia before proving or otherwise its true haematological properties.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
