Abstract
Brain frailty may be related to the pathophysiology of poor clinical outcomes in chronic obstructive pulmonary disease (COPD). This study examines the relationship between hippocampal subfield volumes and frailty and depressive symptoms, and their combined association with quality of life (QOL) in patients with COPD. The study involved 40 patients with COPD. Frailty, depressive symptoms and QOL were assessed using Kihon Checklist (KCL), Hospital Anxiety and Depression Scale (HADS), and World Health Organization Quality of Life Assessment (WHO/QOL-26). Anatomical MRI data were acquired, and volumes of the hippocampal subfields were obtained using FreeSurfer (version 6.0). Statistically, HADS score had significant association with WHO/QOL-26 and KCL scores. KCL scores were significantly associated with volumes of left and right whole hippocampi, presubiculum and subiculum, but HADS score had no significant association with whole hippocampi or hippocampal subfield volumes. Meanwhile, WHO/QOL-26 score was significantly associated with volume of the left CA1. There was a significant association between frailty, depression, and QOL. Hippocampal pathology was related to frailty and, to some extent, with QOL in patients with COPD. Our results suggest the impact of frailty on hippocampal volume and their combined associations with poor QOL in COPD.
Highlights
Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic disease, the progressive course of which impacts upon mortality and disturbs various aspects of the patient’s life [1,2]
In patients with COPD, poor clinical outcomes and a higher rate of mortality are associated with frailty [10,11,12] and co-morbid depression [13,14,15,16,17,18]
Hospital Anxiety and Depression Scale (HADS) and Kihon Checklist (KCL) scores were significantly higher in the low quality of life (QOL) group compared with those in the high and moderate QOL groups (Table S1)
Summary
Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic disease, the progressive course of which impacts upon mortality and disturbs various aspects of the patient’s life [1,2]. Chronic systemic inflammatory reaction causes extra-pulmonary manifestation in COPD, such as motor and psychiatric symptoms [3,4,5,6,7]. Systematic review and meta-analyses have reported the prevalence of frailty and depression in patients with. In patients with COPD, poor clinical outcomes and a higher rate of mortality are associated with frailty [10,11,12] and co-morbid depression [13,14,15,16,17,18].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
