Abstract
Prior fMRI studies have shown impairments in reinforcement-based decision making caused by disrupted expected value (EV) and prediction error (PE) signaling within the insula, ventromedial prefrontal cortex, and caudate among youths with disruptive behavior disorders (DBDs). Dysfunction in the serotonergic system has been suggested as a potential mechanism for DBDs, and serotonergic agents are known to decrease DBD symptoms. However, few studies have explored how treatment impacts neural areas implicated in the pathophysiology. Therefore, this study preliminarily investigates the impact of fluoxetine on disruptive EV and PE signaling in youths with DBD.
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