Impact of Female Obesity on Cumulative Live Birth Rates in the First Complete Ovarian Stimulation Cycle.

Wen Ding,Xiao-Cong Liu,Shan-Jun Dai,Gang Li,Lin-Li Hu,Fu-Li Zhang,Hui-Juan Kong,Yi-Hong Guo

doi:10.3389/fendo.2019.00516

Abstract

Background: Female overweight/obesity has been reported to be associated with compromised pregnancy outcomes in fresh embryo transfer cycles. It is unclear whether the cumulative live birth rate (CLBR) is adversely affected after all viable embryos are transferred from the first ovarian stimulation cycle.Objectives: To investigate whether the CLBR was compromised in obese women.Method: A total of 9,772 young women underwent their first IVF/ICSI cycles from January 2012 to October 2017. Pregnancy outcomes were compared according to female BMI.Results: Among 1,671 women with polycystic ovary syndrome (PCOS), those with a BMI ≥ 28 kg/m2 had a lower cumulative clinical pregnancy rate (CCPR) and CLBR during the first complete ovarian stimulation cycle. Additionally, the pregnancy loss rate was increased in this group, although the difference was not significant. Among the 8,101 women without PCOS, the CCPR and CLBR of obese patients was also significantly decreased, and this group also showed increased pregnancy loss rates. Moreover, overweight women also had a decreased CLBR.Conclusions: Female obesity adversely affected the CLBR after utilizing the viable embryos from first oocytes retrieval.

Highlights

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women, is the main cause of ovulatory infertility
Female overweight/obesity has been associated with compromised pregnancy outcomes in fresh embryo transfer cycles, while the effect of female BMI on the cumulative live birth rate (CLBR) is unclear
Among patients without PCOS, the number of oocytes yield was statistically different between the normal weight and overweight patients (P = 0.013); otherwise, no significant differences were observed for women with PCOS among the three BMI groups

Summary

Introduction

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women, is the main cause of ovulatory infertility. A prospective study from nine hospitals in China reported that, among women with PCOS, the ongoing pregnancy rate was similar for women with a high BMI [7]. Female overweight/obesity has been associated with compromised pregnancy outcomes in fresh embryo transfer cycles, while the effect of female BMI on the cumulative live birth rate (CLBR) is unclear. Female overweight/obesity has been reported to be associated with compromised pregnancy outcomes in fresh embryo transfer cycles. It is unclear whether the cumulative live birth rate (CLBR) is adversely affected after all viable embryos are transferred from the first ovarian stimulation cycle

Objectives

Methods

Results

Conclusion