Abstract
To provide female age-related estimates of fecundity and incidence of infertility by history of prior pregnancy among women 30-44years of age. Prospective, time-to-pregnancy cohort study. Not applicable. Women, between 30 and 44years of age, attempting to conceive for ≤3months, and no known history of infertility, polycystic ovarian syndrome (PCOS), or endometriosis. Not applicable. Fecundability and incidence of infertility. Compared to women aged 30-31years, fecundability was reduced by 14% in women 34-35years of age (fecundability ratio [FR] 0.86, 95% confidence interval [CI] 0.68-1.08), 19% in women 36-37years of age (FR 0.81, 95% CI 0.60-1.08, 30% in women 38-39years of age (FR 0.70, 95% CI 0.48-1.01), 53% in women 40-41years of age (FR 0.47, 95% CI 0.28-0.78), and 59% in women 42-44years of age (FR 0.39, 95% CI 0.16-0.93). Fecundability did not differ between women aged 30-31years and 32-33years. In general, fecundability and cumulative probability of pregnancy was lower for women who had never had a prior pregnancy. Women experience a significant reduction in fecundity and increase in the probability of infertility in their late thirties. At any age >30years, women who have never conceived have a lower probability of achieving a pregnancy. NCT01028365.
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