Impact of endocrine disrupting chemicals (EDCs) on the predisposition of cancer and polycystic ovary syndrome (PCOS): A Note

Abstract

Endocrine Disrupting Chemicals (EDCs) or Endocrine Disruptors are unique assemblage or cluster of emerging pollutants as they affect the synthesis, release and transport of hormones. EDCs have been associated with a diverse array of health issues and diseases. EDCs can alter the endocrine system and are involved in carcinogenesis and inducing poly-cystic ovary syndrome (PCOS). The objective of this article is to furnish an outline of research on environmental aspects of EDCs and their effects on human health specially on cancer and PCOS based on evidence from animal and human studies. EDCs include natural compounds such as phytoestrogens and various synthetic chemicals which are utilized by the chemical, agriculture, cosmetic and food industries. Several EDCs may work as carcinogens and causes initiation and advancement of cancer. Uterine and ovarian cancers of female have been associated with exposure to EDC. Bisphenol-A (BPA), an EDC which is found in plastic bottles, household materials, canned food, waste water, beverage containers and thermal paper, can increase risk of breast cancer. Even low levels of BPA exposure may poses threat of prostate cancer in men. Testicular cancer and thyroid cancer could be influenced by EDCs. Comprehensive studies have been conducted by many researchers in the light of toxicity pattern of EDC that render interpretation of impact of EDCs on development of cancer and PCOS inducing capacity in female reproductive system.
 Keywords: Endocrine disrupting chemicals; EDC; Cancer; Endocrine Disruptor, Poly-Cystic Ovary Syndrome; PCOS