IMPACT OF ELECTROLYTE IMBALANCES ON SHORT-TERM IN-HOSPITAL OUTCOMES IN PATIENTS WITH PULMONARY EMBOLISM

Abstract

SESSION TITLE: Monday Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/21/2019 02:30 PM - 03:15 PM PURPOSE: Pulmonary embolism (PE) is a common condition with significant comorbidity and mortality and remains a significant cause of high healthcare costs and hospital admissions. Previous studies have explored the risks of those patients with pulmonary embolism and particular comorbidities in relation to in-hospital outcomes. This study aims to further investigate short-term in-hospital outcomes of patients with the diagnosis of pulmonary embolism and the comorbid condition of electrolyte imbalances (EI). METHODS: This retrospective cohort study utilized data from the 2012-2015Q3 Nationwide Inpatient Sample. ICD-9 codes identified adult patients (age 18+) with the principal diagnosis of PE, and then further isolated patients diagnosed with electrolyte imbalances. Patients with principal diagnoses of respiratory failure or DVT were also included so long as they had a secondary diagnosis of PE. Data for patients who were missing important clinical identifiers (age, gender, race, mortality) were excluded. Patients diagnosed with acute cor pulmonale, iatrogenic PE, septic PE, and PE secondary to obstetrical complications were excluded to isolate diagnoses of PE arising de novo. Data analyses assessed hospital length of stay, inpatient charges, average age of admission, and mortality rate. RESULTS: Of the 857 encounters with patients diagnosed with PE, 248 patients had the comorbid diagnosis of EI. Hospital length of stay was significantly longer in those with the diagnosis of PE and EI (8.00 days with EI vs 5.98 days with no EI, p = 0.001) Total hospital charges were significantly increased ($89,373.65 with EI vs $54,186.61 with no EI, p < 0.0001) Mean mortality rate was significantly higher (10.5% with EI vs 4.9% with no EI, p = 0.005) CONCLUSIONS: This study aims to inform physicians to better manage patients with PE also diagnosed with electrolyte imbalances. These patients have a longer LOS, increased total hospital charges, and higher mortality rate than those without EI.. Future research should aim to investigate different levels of EI prior to determining treatment of those patients that present with PE. CLINICAL IMPLICATIONS: These findings suggest that optimizing management of electrolyte imbalances may be critical for improving hospital outcomes for patients with the diagnosis of PE. DISCLOSURES: No relevant relationships by Tatum Colburn, source=Web Response No relevant relationships by Anthony Olinger, source=Web Response No relevant relationships by Karen Tong, source=Web Response No relevant relationships by Angela Wang-Selfridge, source=Web Response