Abstract
Coronary artery disease (CAD) is a major public health problem in India and is one of the leading causes of mortality and morbidity. Impairment of heart rate variability (HRV) has been observed in patients with CAD. Percutaneous transluminal coronary angioplasty (PTCA) is one of the common modalities of treatment of CAD. In this study we have studied the effect of successful elective PTCA on HRV parameters in patients with CAD. Material and Method: HRV parameters in both time and frequency domain were studied in 30 male patients before PTCA, one day and three day after PTCA. Results: - The time and frequency domain parameters between pre PTCA and 1st day post PTCA were not found to be statistically significant. Changes in the time domain parameter rMSSD and SDNN was statistically significant between pre and 3rd day post PTCA but no significant difference was observed in pNN50. A significant decrease in LF n.u and increase in HF n.u was observed between pre and 3rd day post PTCA. Conclusion: Revascularization with PTCA results in improvement of the autonomic tone. Improved autonomic modulation is seen as early as 3rd day post PTCA. It indicates that restoring the blood flow reverses to some extent the autonomic modulatory effect of coronary artery disease.
Highlights
Heart rate variability (HRV) is defined as the physiological variation in the duration of intervals between sinus beats[1]
Material and Method: HRV parameters in both time and frequency domain were studied in 30 male patients before Percutaneous transluminal coronary angioplasty (PTCA), one day and three day after PTCA
Improved autonomic modulation is seen as early as 3rd day post PTCA. It indicates that restoring the blood flow reverses to some extent the autonomic modulatory effect of coronary artery disease
Summary
Heart rate variability (HRV) is defined as the physiological variation in the duration of intervals between sinus beats[1]. The property of automaticity is intrinsic to the pacemaker tissue of the heart but the rate and rhythm are influenced by the autonomic nervous system. HRV reflects the activity of the divisions of the autonomic nervous system on the heart rate (HR)[2]. HRV is altered in conditions such as obesity, diabetes mellitus, asthma and coronary artery disease(CAD). Coronary artery disease is a major public health problem in India and is one of the leading causes of mortality and morbidity[3]. Impairment of HRV in CAD has been extensively studied and has been attributed to arrythmias and risk of sudden cardiac deaths[4,5,6]. PTCA is one of the common modalities of treatment of CAD.
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