Abstract
BackgroundEarly onset peritonitis (EOP) is not uncommon in peritoneal dialysis patients. We aimed to compare the prognosis of EOP and non-EOP peritoneal dialysis patients.MethodsThis study included subjects that underwent PD from January 1, 2004 to July 31, 2013. Patient characteristics were collected. EOP was defined as peritonitis occurring within 6 months after initiation of PD. Patient and technique survival were compared between EOP and non-EOP patients using Cox regression analyses.ResultsIn total, 189 subjects were included in this study. Patients were divided into EOP (n = 55) and non-EOP groups (n = 134). There was no significant difference in the causative organisms of peritonitis between the two groups. After adjusting for age, diabetes status, serum albumin level and residual renal function, the multivariable Cox regression model revealed that EOP was an independent risk factor for patient mortality (HR 2.03, RI 1.09–3.80, p = 0.026), technique failure (HR 1.69, RI 1.12–2.87, p = 0.015) and total survival (HR 1.73, RI 1.12–2.68, p = 0.013).ConclusionsEOP was identified as an independent risk factor for mortality and technique failure in peritoneal dialysis patients.
Highlights
Onset peritonitis (EOP) is not uncommon in peritoneal dialysis patients
Several studies have already been conducted to assess the impact of early onset peritonitis (EOP) on outcomes in Peritoneal dialysis (PD) patients
We aimed to compare the prognosis of Early onset peritonitis (EOP) and non-EOP peritoneal dialysis patients
Summary
Onset peritonitis (EOP) is not uncommon in peritoneal dialysis patients. In the BRZPD study (Martin et al 2011), the median time from PD initiation to first peritonitis episode was found to be 6 months. Another study showed that during the first year after PD, more than 70 % of patients had their first peritonitis episode within 6 months (Pulliam et al 2014). Several studies have already been conducted to assess the impact of early onset peritonitis (EOP) on outcomes in PD patients. EOP has not been defined consistently, with definitions varying from 3 to 24 months after PD commencement (Fourtounas et al 2006; Harel et al 2006; Hsieh et al 2014). Previous results were not convincing due to the absence of significant findings in and relatively small sample sizes of these studies (Fourtounas et al 2006; Harel et al 2006)
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