Abstract
BackgroundMetabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome.MethodsWe used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle.ResultsIt was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides.ConclusionNeither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome.
Highlights
Metabolic syndrome is a disease that today affects millions of people around the world
In search of a suitable experimental model to study the role of exercise in the treatment of metabolic syndrome, this study examined the metabolic profile as well as glucose uptake by skeletal muscle and aerobic capacity of rats maintained on a fructose-rich diet during intrauterine and postnatal life
The groups fed with the fructose-rich diet (F and Fructose/Small litter (FS)) had lower body weight than controls, with the lowest values given by the group kept in appropriate litters during lactation (F)
Summary
Metabolic syndrome is a disease that today affects millions of people around the world. The metabolic syndrome, known as X syndrome or insulin resistance syndrome comprises a spectrum of disorders in which impaired glucose tolerance represents one of the most important. These changes include insulin resistance, with or without type 2 diabetes mellitus, hypertension, obesity, dyslipidemia, endothelial dysfunction, among others [1]. In 2002, only in this country, according to estimations, there were more than 47 million people with manifestations of this syndrome [2]. Reaven [3] suggested a strong association between individuals with the same
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