Impact of drug carrier shape, size, porosity and blood rheology on magnetic nanoparticle-based drug delivery in a microvessel

Abstract

Background and objectiveIn the drug targeting delivery, the mesoporous materials known as biomaterials exhibit a more significant drug loading and drug release capacity at a specific location are controlled by the external magnetic field. This article theoretically investigates the effects of a high specific surface, pore volume and unique pore size enrich mesoporous materials as carriers for magnetic drug targeting delivery. We analyze the trajectory of a porous drug carrier embedded with the magnetic nanoparticles are transported with the blood flow through the microvessel. MethodsThe governing equations for blood flow and the motion of the magnetic nanoparticles are solved analytically in terms of the Bessel function. The solutions have been computed numerically to discuss the effects of size and permeability of the carrier particle, the volume fraction of embedded magnetic nanoparticles, distance of the magnetic from the axis of the microvessel,the intensity of the magnetic field, blood rheology, the shape of the carrier particles and Saffman force on flow analysis. ResultsThe permeability of the drug carrier and the peripheral region support the drug carrier to capture near the tumor zone, while the stress jump is constant and Saffman parameter shows an opposite phenomenon. Due to symmetricity, the spherical particles easily capture at the tumor zone rather than the arbitrarily shaped drug carrier. Blood rheology based yield stress reduces the efficiency of the drug carrier to capture close to the tumor region. The trajectories of the drug carrier towards the tumor are restricted with an increase in the aspect ratio of the cylinder. The same phenomena are observed for the increased aspect ratio of the prolate ellipsoid. The outcomes of the present analysis will help to develop biomaterials in the drug delivery applications.