Impact of Disulfide/Thiol Redox Couple on Pulse Wave Velocity in Patients with Normal Coronary Angiography

Abstract

Introduction: The oxidized thiol/disulfide couple has been investigated and reported as a potential risk factor for cardiovascular diseases. Additionally, an increased pulse wave velocity has been identified as a predictor of cardiovascular events. Patients and Methods: 262 patients were included in our study. Native and total thiol levels, total disulfide levels, disulfide per total thiol ratios, native thiol per total thiol ratios, and disulfide per native thiol level ratios were calculated. Results: Patients were divided into Pulse Wave Velocity (PWV) low and PWV high groups. Native and total thiol levels were higher in PWV low group compared to PWV high group (p< 0.001 for both). The median disulfide value was higher in PWV high group (p= 0.002). Disulfide per native thiol and disulfide per total thiol ratio values were higher in PWV high group (p< 0.001). Native thiol per total thiol ratios were higher in the PWV-low group (p< 0.001). Conclusion: The disulfide/native thiol pathway may be an indicator for predicting future atherosclerotic cardiovascular events.