Impact of diphenhydramine hydrochloride on an aqueous solution of imidazolium based surface-active ionic liquids at different temperatures: Physicochemical, thermodynamic and transport studies

Abstract

In order to embrace the synergy between drug diphenhydramine hydrochloride (DPH) and ionic liquids 1-decyl-3-methylimidazolium bromide [C10mim][Br] and 1-dodecyl-3-methylimidazolium bromide [C12mim][Br] in aqueous media, we investigated the thermodynamics and transport properties of binary and ternary system. The calculation of quantities such as apparent molar volume (Vϕ), limiting apparent molar volume (Vοϕ), apparent molar isentropic compressibility (Kϕ) and limiting apparent molar isentropic compressibility (Kοϕ) of DPH in aqueous solution of ionic liquids from the volumetric and acoustic data help us to explore the solute–solute as well as solute–solvent interaction existing in the ternary systems. The apparent molar expansivity (Eoϕ), Hepler's constant (∂Eoϕ/∂T)P have been further determined to assist the interpretations earned from the volumetric and acoustic analysis. In addition, using the Jones–Dole equation, viscosity B-coefficients and temperature derivative of B-coefficients (dB/dT) have been determined. By using co-sphere overlap model of ternary mixtures we have studied the different types of interaction prevailing in the DPH and aqueous ionic liquids solution. The dominance of ionic-hydrophilic and hydrophilic-hydrophilic interactions in the ternary system is indicated by the positive and increasing ΔtrVϕ0 and ΔtrKοΦ values with increasing ILs concentration. Finally, the structure making nature of the DPH in aqueous ionic liquid solution is confirmed by the Hepler’s constant and viscosity B- coefficients.