Impact of diastolic dysfunction on global contractile capacity on the level of the myofilaments

Abstract

Objectives: Diastolic dysfunction (DD) accounts for as many as 40% of all cases of congestive heart failure (CHF). The prevalence of diastolic heart failure (DHF) in patients with normal systolic function increases with age and is significantly higher in women than in other groups: up to 75% of patients who have diastolic heart failure are women. In the progression of most cardiac diseases, diastolic dysfunction precedes systolic impairment. Because of lack of data, there are no therapeutic recommendations for treatment. Therefore we performed a study to compare the cardiac capacity of the contractile elements of patients with (Group I) and without diastolic dysfunction (Group II).