Abstract
The purpose of study was to evaluate the impact of depressive symptoms on the QoL in patients following acute coronary syndrome treated with percutaneous coronary intervention (PCI) at week one of hospitalization and 6 months following ACS. Methods The study population included 140 patients hospitalized for acute coronary syndrome who underwent PCI. Depression was evaluated using the Beck Depression Index, which is a self-scoring test for symptoms and severity of depression composed of 21 questions. QoL was evaluated with the use of the Mac New questionnaire, specifically designed for cardiology patients. The QoL evaluation in all Mac New dimensions in the depressed and not depressed groups was statistically different both at baseline and at 6-month follow up. At baseline and at the 6- month follow-up, the mean Emotional Dimension, Physical Dimension, Social Dimension and evaluation of the General Quality of Life dimension the results were lower in the depressed group compared with the not depressed group. The dynamics of change in QoL at 6 months following PCI was verified using the Wilcoxon test and a statistically significant improvement in quality of life was found in all Mac New dimensions in both groups. However, the dynamics were more beneficial in the depressed group. Depression in ACS patients has a strong negative effect on QoL both in early and late observations. Early depression, on the other hand, is a statistically significant and independent predictor of a lower QoL outcome. As such, diagnosis and treatment of depression in patients hospitalized with ACS should become a therapeutic standard.
Highlights
The purpose of the treatment of acute coronary syndromes (ACS) is improvement in patients’ health, which means that it is designed to reduce mortality, and to improve functional outcomes and quality of life in this group of patients [1]
A recent meta-analysis of 22 studies suggested that the effects of depression following myocardial infarction on cardiac prognosis were at least partly confounded by the severity of the infarction
The purpose of this study is to evaluate the impact of depression on the quality of life in patients following acute coronary syndrome treated with percutaneous coronary intervention (PCI) at week one of hospitalization and 6 months following infarction
Summary
The purpose of the treatment of acute coronary syndromes (ACS) is improvement in patients’ health, which means that it is designed to reduce mortality, and to improve functional outcomes and quality of life in this group of patients [1]. Symptoms of depression can be observed in 45% of patients hospitalized for acute coronary syndromes. These greatly hinder the achievement of the desired therapeutic goal, increase the risk of early and late mortality, and impair patient quality of life [2,3]. Post-myocardial infarction depression was associated with a 2-2.5 times increased risk of all-cause mortality, cardiac mortality, and new cardiovascular events [4]. Patients with depression respond less well to treatment and are not actively involved in the therapeutic process [2]
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