Impact of Depression and Anxiety on Dimensions of Health-Related Quality of Life in Subjects with Parkinson's Disease Enrolled in an Association of Patients.

Fany Chuquilín-Arista,Tania Álvarez-Avellón,Manuel Menéndez-González

doi:10.3390/brainsci11060771

Abstract

Parkinson’s disease (PD) is a complex disorder characterized by a wide spectrum of symptoms. Depression and anxiety are common manifestations in PD and may be determinants of health-related quality of life (HRQoL). The objective of this study is to determine the association of depression and anxiety with the dimensions of HRQoL in subjects with PD enrolled in an association of patients. Ninety-five community-based patients with PD diagnosis at different disease stages were studied. HRQoL was assessed using the Parkinson’s Disease Questionnaire (PDQ-39); depression and anxiety were assessed using the Beck Depression Inventory (BDI-II) and the State-Trait Anxiety Inventory (STAI), respectively. Our results showed that depression and anxiety were negatively associated with HRQoL measured by PDSI. Higher motor dysfunction measured by Hoehn and Yahr (H&Y) staging was also associated with worse HRQoL. Depression was the most influential variable in the model. All PDQ-39 dimensions except social support and bodily discomfort were associated with depression. Anxiety was associated with the emotional well-being and bodily discomfort dimensions. These results suggest that physicians should pay attention to the presence of psychiatric symptoms and treat them appropriately.

Highlights

Introduction published maps and institutional affilQuality of life (QoL) is defined by the World Health Organization (WHO) as “individuals’ perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards, and concerns” [1]
The main finding of this study is that neuropsychiatric symptoms have a great influence on global health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD)
We found no association between age, civil status, or family history and global HRQoL measured by PDSI and any PDQ-39 dimensions in multivariate analysis

Summary

Introduction

Quality of life (QoL) is defined by the World Health Organization (WHO) as “individuals’ perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards, and concerns” [1]. HRQoL is defined as “the perception and evaluation by patients themselves of the impact caused on their life by the disease and its consequences” [2]. The disease involves prominent motor symptoms and causes neuropsychiatric symptoms such as depression and anxiety. These neuropsychiatric symptoms are frequently overlooked and/or unreported [4] and might have a great impact on the patient’s QoL and on the different dimensions of HRQoL [5]

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