Impact of COVID-19 vaccination drive against COVID-19 illness and deaths in a tertiary care centre

Abstract

Introduction: In response to the COVID-19 pandemic, worldwide efforts to develop vaccines to give protection against COVID-19. Despite the record speed at which have been developed, COVID-19 vaccines have still been subject to the same checks, balances, and scientific and regulatory rigour as any other vaccine, and shown to be safe. The study aimed to establish the relationship of vaccination on length of stay. Materials and methods: A retrospective cohort study was carried out among all 1123 COVID-19 patients admitted or discharged during March 2021 to June 2021 at tertiary care centre. Hospital records of all COVID-19 patients admitted during study duration were assessed for the required information and also telephonic interview taken if needed. Descriptive statistics were used to assess the distribution of factors among the patients. Results: Of total 1123 inpatients, 21.7% had received a single dose of COVID-19 vaccine while 74.9% had not received any form of COVID-19 vaccination. Mean length of stay in hospital was similar (7.6 days). Among all, 81.3% were nonvaccinated. The mean length of stay in ICU for the two doses received vaccinated was 4.2 ± 3.0 days while unvaccinated patients was 5.1 ± 2.6 days. Mortality rate was 3.6% patients in the two doses vaccinated group and 74.4% in the non-vaccinated group found. Conclusion: Among vaccinated patients there was a 75% relative risk reduction in ICU admission. There was no difference observed in duration of stay among vaccinated or unvaccinated patients, deaths among comorbid patients.