Abstract
Contact and intrinsic coagulation pathway components are involved in pathological thrombus formation. In addition to coagulation, contact system activation is involved in anti/profibrinolytic and inflammatory processes that can contribute to the atherosclerotic and thrombotic environment, leading to cardiovascular diseases. This literature review concerns the role of the contact system on cardiovascular diseases and accentuates the potential of coagulation factors FXII (FXII) and FXI (FXI) as targets for antithrombotic therapy.
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