Abstract
This cross-sectional study aimed to investigate the association between hyperuricemia and the frequency of coffee, tea, and soft drink consumption, based on data from the Korean Genome and Epidemiology Study (KoGES) (2004–2016). We used the KoGES health examinee data, obtained from urban residents aged ≥ 40 years. Information on the participants’ medical history, nutrition (total calorie, protein, fat, and carbohydrate intake), frequency of alcohol consumption, smoking status, household income, and frequency of coffee/green tea/soft drink intake was collected. A logistic regression model was used to analyze the data. Subgroup analyses were performed according to the participant’s age and sex. Among 173,209 participants, there were 11,750 and 156,002 individuals with hyperuricemia and non-hyperuricemia controls, respectively. In an adjusted model, frequent coffee and green tea consumption did not increase the risk of hyperuricemia, compared to the “no intake” reference group. However, an adjusted odds ratio of hyperuricemia was 1.23 (95% confidence interval, 1.11–1.35, p < 0.001) for participants who reported consuming soft drinks ≥ 3 times per day, compared to the respective “no drink” reference group. Even after adjusting for nutritional and sociodemographic factors, frequent soft drink intake was associated with an increased risk of hyperuricemia. Meanwhile, neither coffee nor green tea intake was associated with an increased risk of hyperuricemia.
Highlights
According to the National Health and Nutrition Examination Survey, 21% of Northern America’s adult population aged > 20 years are affected by hyperuricemia [5]
“never” in their consumption; this association remained after adjustments for sociodemo“never” in their consumption; this association remained after adjustments for graphic and nutritional factors
Adjusting in relation to nutritional factors is in this type of study, as nutrition can affect the level of serum uric acid
Summary
Hyperuricemia is the main risk factor for gout and plays a major role in its pathogenesis [1]. Gout is a common form of inflammatory arthritis, characterized by sudden and severe pain, and swelling of the affected joint [2], impairing patients’ quality of life [3]. In addition to being a risk factor for inflammatory arthritis, elevated levels of serum uric acid are associated with an increased risk of cardiovascular disorders [4]. In Korea, the age-standardized prevalence of hyperuricemia has been estimated at 11.4% [6]. Hyperuricemia is prevalent worldwide, and the number of people affected by it has increased over the past two decades [7]
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