Abstract
Purpose: To investigate the impact of the combination of citalopram and mindfulness-based stress reduction (MBSR) on the symptoms, cognitive functions and self-confidence of patients with depression.Methods: A total of 98 patients with depression were selected as study subjects and divided into combination therapy group (CT, n = 51) and conventional group (C, n = 47. The conventional group was treated with citalopram, while the combined group was treated with a combination of citalopram and MBSR. Depressive symptoms and self-confidence were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17) and General Self-efficacy Scale (GSES). Cognitive functions were assessed by Wisconsin Card Sorting Test (WCST) and Trail Making Test (TMT). Changes in depressive symptoms, cognitive functions, self-confidence and clinical efficacies between the two groups were compared.Results: At weeks 1, 4 and 8 after treatment, CT group had lower HAMD-17 scores but higher GSES scores when compared with the conventional group (p < 0.05). In addition, CT group was superior to the conventional group in efficacy and overall response rate (100.00 vs. 85.11 %, p < 0.05). Also, CT group showed a shorter time of perseverative and non-perseverative errors on WCST and a shorter time for TMT-A and TMT-B, compared with the conventional group (p < 0.05).Conclusion: The combination therapy of citalopram and MBSR is effective in ameliorating depressive symptoms, and enhancing cognitive functions and self-confidence in patients with depression. These findings will increase the understanding of this combination therapy, and provide a clinical reference for the treatment of depression.
Highlights
Depression is a common mental disorder induced by genetic factors, mediator dysfunction in the central nervous system, constitutional factors, and mental factors
A study indicated that medication demonstrates an efficacy of appropriately 67 % in the treatment of depression, and the residual depressive symptoms lead to impaired cognitive functions and a dip in the patient’s self-confidence, negatively affecting the efficacy of the medication [3]
This study explores the impact of citalopram combined with Mindfulness-based Stress Reduction (MBSR) on symptoms, cognitive function and self-confidence in patients with depression, so as to provide a reference for the treatment of depression
Summary
Depression is a common mental disorder induced by genetic factors, mediator dysfunction in the central nervous system, constitutional factors, and mental factors. Most patients suffering from depression display signs of cognitive impairment, leading to a lack of the self-confidence needed to overcome the disease, and an inability to restore their social functions as soon as possible [2]. Medication can improve the health of patients already suffering from clinical symptoms of depression such as delusions and hallucinations, as well as control the progression of depression, most patients tend to show a high recurrence rate of depression, a low cure rate, as well as impaired cognitive functions. A study indicated that medication demonstrates an efficacy of appropriately 67 % in the treatment of depression, and the residual depressive symptoms lead to impaired cognitive functions and a dip in the patient’s self-confidence, negatively affecting the efficacy of the medication [3]. Medication combined with psychotherapy remarkably improves the efficacy of medication, improves patients’ cognitive functions, and their ability to regain their self-confidence to overcome it, as well as reduce residual depressive symptoms [4]
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