Impact of chronic lung disease on long-term clinical outcomes in patients with venous thromboembolism: From the COMMAND VTE registry

Abstract

Chronic lung disease (CLD), such as asthma, chronic obstructive pulmonary disease (COPD), and restrictive lung diseases, has been reported to be a moderate risk factor for the development of venous thromboembolism (VTE) [ [1] Keramidas G. Gourgoulianis K.I. Kotsiou O.S. Venous thromboembolic disease in chronic inflammatory lung diseases: knowns and unknowns. J Clin Med. 2021; 10: 2061 Google Scholar ]. In addition, CLD could have a significant impact on acute mortality, and CLD is included in the simplified Pulmonary Embolism Severity Index (sPESI), which is a prognostic score for short-term mortality [ 2 Jiménez D. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med. 2010; 170: 1383 Google Scholar , 3 Bertoletti L. Quenet S. Mismetti P. Hernández L. Martín-Villasclaras J.J. Tolosa C. et al. Clinical presentation and outcome of venous thromboembolism in COPD. Eur Respir J. 2012; 39: 862-868 Google Scholar , 4 Carson J.L. Terrin M.L. Duff A. Kelley M.A. Pulmonary embolism and mortality in patients with COPD. Chest. 1996; 110: 1212-1219 Google Scholar , 5 Le Mao R. Tromeur C. Bazire A. Gouillou M. Guegan M. Lacut K. et al. Risk of recurrent venous thromboembolism in COPD patients: results from a prospective cohort study. Eur Respir J. 2017; 501700094 Google Scholar ]. However, there is still limited data on the impact of CLD on long-term clinical outcomes in patients with VTE. The assessment of the impact of CLD on long-term clinical outcomes is clinically relevant in determining the long-term optimal management strategies for these patients. Thus, we aimed to investigate the clinical characteristics, management strategies, and long-term clinical outcomes by comparing the patients with and without CLD using a large observational database in Japan.