Impact of chronic gliclazide therapy in the nuclear oxidative stress and insulin-resistance levels in an animal model of diabetes

Abstract

Introduction: Type 2 diabetes (DM) is associated with a higher incidence and worse prognosis of ischemic heart disease. High levels of insulin-resistance and nuclear oxidative stress, common in DM, may be involved. However, the mechanisms of these changes in DM and their modulation by chronic administration of gliclazide (a sulphonylurea) are not yet fully known.